Clomibol 50mg (Clomiphene)

What is Clomibol (Clomiphene) 50mg?

Clomibol (Clomiphene) 50mg is a non-steroidal anti-inflammatory drug (NSAID) used to treat infertility. It stimulates the pituitary gland to release the hormones necessary for ovulation (the release of an egg from the ovary).

Clomiphene citrate tablet is used to induce ovulation in women with certain conditions (such as polycystic ovary syndrome) that prevent natural ovulation.

Clomibol, also known by its generic name clomiphene citrate, is a selective estrogen receptor modulator (SERM) most commonly prescribed for the treatment of female infertility. However, it also has a well-documented off-label use in men: to stimulate natural testosterone production after exogenous testosterone has suppressed it.

During testosterone replacement therapy (TRT) or anabolic steroid cycles, natural testosterone production slows down or stops due to the external supply of hormones. Once the cycle is finished, the body needs a boost to restart natural testosterone production. This is where Clomibol (Clomiphene) 50mg can be useful.

How does Clomibol 50mg (Clomiphene) work in PCT?

Clomibol (Clomiphene) 50mg tablet works by blocking estrogen receptors in the brain, specifically in the hypothalamus. This tricks the brain into believing that estrogen levels are lower than they actually are, causing the hypothalamus to release more gonadotropin-releasing hormone (GnRH). In turn, this stimulates the pituitary gland to produce luteinizing hormone (LH) and follicle-stimulating hormone (FSH), two essential hormones for signaling the testes to produce testosterone.

In other words, it helps restart the hormonal feedback loop that is often suppressed during testosterone replacement therapy (TRT) or steroid use.

Benefits of Clomibol (Clomiphene) 50mg in PCT

1. Restoration of natural testosterone levels:

Testosterone suppression during a steroid cycle can be profound. By stimulating the production of LH and FSH, Clomibol (Clomiphene) 50mg helps the testes resume normal testosterone production.

This process is crucial to prevent a post-cycle crash, where testosterone levels could plummet, leading to significant muscle loss and other negative health effects.

2. Preservation of muscle mass:

High testosterone levels are essential for maintaining muscle mass. Without proper PCT, a reduction in testosterone can lead to catabolism, or the breakdown of muscle tissue.

Clomibol (Clomiphene) 50mg tablet helps maintain anabolic (muscle-building) conditions by ensuring adequate testosterone levels, thus preserving the muscle gains achieved during the steroid cycle.

3. Improved mood and energy levels:

Testosterone influences mood, energy levels, and overall well-being. Low testosterone levels can cause depression, fatigue, and irritability.

By normalizing testosterone levels, Clomibol (Clomiphene) 50mg helps stabilize mood and energy, thus improving mental and physical health.

4. Reduced risk of estrogenic side effects:

Although Clomibol (Clomiphene) 50mg primarily works by blocking estrogen receptors to stimulate testosterone production, it also indirectly helps manage estrogen-related side effects.

High estrogen levels after a cycle can lead to gynecomastia (development of breast tissue in men) and water retention.

By modulating the body’s response to estrogen, Clomibol (Clomiphene) 50mg helps mitigate these risks.

What is PCT (Post-Cycle Therapy)?

Post-cycle therapy (PCT) is the phase during which most steroid users choose to take Clomibol (Clomiphene) 50mg. PCT is the process that follows a steroid cycle and aims to restore normal testosterone function.

How to Use Clomibol (Clomiphene) 50mg for PCT?

Using Clomibol (Clomiphene) 50mg as part of post-cycle therapy (PCT) requires careful consideration of timing, dosage, and duration, as well as consultation with a doctor.

Here is a detailed protocol:

Timing:

The optimal time to start Clomibol (Clomiphene) 50mg therapy is approximately two weeks after the last steroid injection. However, this timeframe depends on the type of anabolic steroid used. For example, if using short-ester steroids like testosterone propionate, you can start Clomiphene PCT one or two days before the last injection.

On the other hand, if using long-ester steroids like testosterone enanthate, you need to wait two to three weeks (14 to 21 days) before starting Clomiphene therapy. This allows the synthetic steroids to be properly eliminated from the body, making the PCT more effective.

Starting too early may not give the body enough time to adjust, while starting too late can prolong the period of low testosterone levels.

Dosage:

A typical Clomibol (Clomiphene) 50mg protocol starts with a higher dose to kickstart the process, followed by a gradual reduction.

Here is a typical protocol:

• Week 1: Start with 100 mg per day. This higher dose allows for a rapid increase in LH and FSH levels.
• Weeks 2-3: Reduce to 50 mg per day. This maintains the stimulation of testosterone production, allowing the body to adapt.
• Week 4: Gradually reduce to 25 mg per day. This final step helps the body return to normal hormonal balance without abrupt changes.

It is also important to note that the Clomibol (Clomiphene) 50mg protocol can vary considerably and depends on the steroid dosage and cycle duration. It is therefore important to remember that the Oral Clomibol protocol can be adapted to individual needs, and this also applies to the use of it alone or in combination with other compounds such as Nolvadex or HCG during the PCT protocol.

Duration:

The duration of Clomibol (Clomiphene) 50mg use typically ranges from 4 to 6 weeks, depending on the length and intensity of the steroid cycle. Shorter cycles may only require 4 weeks, while longer and more intense cycles may require as much as 6 weeks to ensure complete recovery.

Side effects and precautions

Although Oral Clomibol (Clomiphene) 50mg is generally well tolerated, some patients may experience the following side effects:

• Mood swings or irritability
• Visual disturbances (blurred vision, floaters)
• Nausea
• Headache
• Breast pain

It is also important to note that Clomibol (Clomiphene) 50mg is not effective for everyone and that excessive or inappropriate use can lead to hormonal imbalances or prolonged suppression of ovulation.

Therefore, it should only be used under medical supervision, with regular blood tests to monitor hormone levels and adjust treatment accordingly.

What other medications can interact with clomiphene?

Other medications may interact with clomiphene, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell all your healthcare providers about all the medications you are taking and any that you start or stop taking.

Clomiphene drug interactions (more detail)

Clomibol (Clomiphene) 50mg vs. Other Post-Cycle Therapy (PCT) Options

We are fortunate to have several options for post-cycle therapy (PCT). The choice of products to use during the PCT cycle (and the duration of their use) will depend on the drugs you have access to, the steroids you have taken, the duration of their use, and your sensitivity to certain side effects of these drugs, whether they are products used during the cycle or during PCT. Therefore, it is important to compare Clomibol (Clomiphene) 50mg with other common options: Nolvadex, HCG, and Letrozole.

FAQ’S

Medical Disclaimer

The following information is provided for informational purposes only and does not constitute medical advice. Clomibol contains clomiphene citrate, a Schedule 4 medication (prescription-only) in Australia. This is a powerful fertility drug that should only be taken under strict medical supervision. Misuse can lead to ovarian hyperstimulation, visual disturbances, and hormonal imbalance.

References 

• Clomiphene (oral route). (2025, April 1). Mayo Clinic. https://www.mayoclinic.org/drugs-supplements/clomiphene-oral-route/description/drg-20063072
• “Clomiphene: Uses, Dosage, Side Effects.” Drugs.com, www.drugs.com/clomiphene.html.